1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.218
Position:
61579463
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
9.173
Reference Allele:
A
-log10(P):
-44.530
MAF:
0.337
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.114
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.4[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes; lower FADS1/FADS2 function decreases docosapentaenoate (product) and may alter the incorporation of fatty acids into phospholipids.3[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids and their phospholipid products.2[1], 7[2] This dysregulation of lipid metabolism is linked to phenotypes like hypercholesterolemia and inflammatory conditions such as cholelithiasis and IBD.7[3], 8[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data