1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1219549

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.167
Position:
75454622
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
7.545
Reference Allele:
T
-log10(P):
-30.730
MAF:
0.162
Beta (Num):
0.102
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.065
SE (Den):
0.020
No CNV overlap
rQTL cluster:
56
Reaction Distance:
NA
Closest Genes:
MOGAT2 DGAT2 UVRAG MAP6 SERPINH1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) reflects membrane composition and lipid homeostasis.6[1], 7[2] PDXDC1 variants are associated with altered levels of both.8[3], 9[4], 2[5], 3[6]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in PDXDC1 is associated with altered phospholipid levels.1[1], 2[2], 3[3] Changes in the PE/PC ratio affect membrane integrity and are linked to gout and altered red blood cell/lipid parameters.6[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:PDXDC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data