1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.176
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
11.374
Reference Allele:
A
-log10(P):
-67.346
MAF:
0.343
Beta (Num):
0.106
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.070
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs3734398

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.126
Position:
10982973
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
8.462
Reference Allele:
T
-log10(P):
-38.182
MAF:
0.426
Beta (Num):
0.048
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between the synthesis of phosphatidylethanolamines containing oleic acid versus docosahexaenoic acid, influenced by FADS desaturase activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, impacting the balance of polyunsaturated fatty acids.1[1], 2[2], 3[3] This dysregulation is linked to various phenotypes, including cardiovascular diseases and inflammatory conditions like asthma and dermatitis.8[4], 9[5], 10[6], 11[7], 12[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data