1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.446
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
24.891
Reference Allele:
A
-log10(P):
-313.230
MAF:
0.343
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.340
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis5[1], 6[2]

Ratio Explanation:

This ratio reflects fatty acid desaturase (FADS) activity; higher levels may indicate reduced FADS function, impacting the balance of oleic and arachidonic acid-containing lipids.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, alters polyunsaturated fatty acid levels, which is linked to inflammation and disordered lipid metabolism, core components of associated phenotypes like cholelithiasis and benign colon neoplasms.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data