1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.433
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
22.142
Reference Allele:
A
-log10(P):
-248.455
MAF:
0.343
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerolipid metabolism, PUFA biosynthesis.6[1]

Ratio Explanation:

This ratio reflects the activity of FADS1 and FADS2 enzymes, indicating the conversion rate of linoleic acid to arachidonic acid, a key step in fatty acid metabolism.1[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid desaturation, affecting the availability of arachidonic acid, a precursor for inflammatory mediators.7[1] This dysregulation is linked to inflammatory and metabolic phenotypes like cholelithiasis and Type 2 diabetes, which are associated with these genetic loci.8[2], 9[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data