1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.259
Position:
61569830
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
9.881
Reference Allele:
C
-log10(P):
-51.345
MAF:
0.339
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.155
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Very-long-chain polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio of a glycerophospholipid to a very-long-chain fatty acid may reflect the activity of FADS2, which is involved in the synthesis of both components.2[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, reflected in the metabolite ratio, impacts lipid profiles. This is linked to metabolic and inflammatory phenotypes like hypercholesterolemia, cholelithiasis, and type 2 diabetes, where lipid dysregulation and inflammation are key pathological factors.1[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data