1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.303
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
14.253
Reference Allele:
A
-log10(P):
-104.457
MAF:
0.344
Beta (Num):
0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.120
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

This ratio reflects the activity of FADS2, which synthesizes the denominator stearidonate, relative to the synthesis of the GPI-anchored lipid in the numerator.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are linked to altered polyunsaturated fatty acid levels and inflammation, influencing risk for inflammatory conditions like IBD and dermatitis, and metabolic disorders such as hypercholesterolemia and type 2 diabetes, which are associated with this ratio.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data