1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.293
Position:
61581764
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
13.405
Reference Allele:
T
-log10(P):
-92.669
MAF:
0.309
Beta (Num):
0.178
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects FADS1 activity on the fatty acid pool. FADS1 influences the availability of specific fatty acid chains for incorporation into different lipids.8[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 variants alter the synthesis of PUFAs, which are precursors to inflammatory mediators and key components of lipid profiles.10[1], 11[2], 9[3] This directly impacts phenotypes like inflammatory conditions (asthma, sinusitis, phlebitis) and lipid metabolism disorders (hypercholesterolaemia), making the ratio a biomarker for FADS1 activity.1[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data