1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.293
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
13.056
Reference Allele:
A
-log10(P):
-88.028
MAF:
0.344
Beta (Num):
0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.110
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylinositol synthesis, GPI-anchor biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, where higher activity would decrease the GPI-anchored saturated/monounsaturated fatty acids and increase downstream n-6 polyunsaturated fatty acids.1[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by the ratio, is linked to altered lipid profiles, including cholesterol metabolism, which is a known risk factor for cholelithiasis and dyslipidemia.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data