1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to 1-(1-enyl-palmitoyl)-gpc (p-16:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.348
Position:
61557803
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
14.674
Reference Allele:
T
-log10(P):
-110.577
MAF:
0.347
Beta (Num):
0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis.6[1], 7[2]

Ratio Explanation:

Ratio reflects the balance between a GPI-anchored lipid containing linoleic acid (18:2) and a plasmalogen, potentially influenced by FADS-mediated PUFA synthesis.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, which is reflected in the membrane lipid composition. This dysregulation of lipid metabolism likely drives the observed associations with hypercholesterolemia and cholelithiasis.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data