1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Metabolite Accession: GCST90200043
Name: 1-palmitoyl-2-docosahexaenoyl-gpc (16:0/22:6)
Hmdb Id: HMDB0007991
Super Pathway: NA
Sub Pathway: NA
Inchikey: IESVDEZGAHUQJU

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.346
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
14.939
Reference Allele:
A
-log10(P):
-114.525
MAF:
0.344
Beta (Num):
0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.163
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis.7[1]

Ratio Explanation:

The ratio reflects FADS desaturase efficiency, where a higher ratio suggests reduced conversion of linoleoyl (18:2) moieties to more unsaturated downstream fatty acids like docosahexaenoyl (22:6).1[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an elevated ratio, alters the balance of omega-6/omega-3 fatty acids. This dysregulation of lipid mediators can contribute to inflammatory conditions like asthma and IBD, and metabolic disturbances such as hypercholesterolaemia and type 2 diabetes.2[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data