1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4985154

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.229
Position:
15131642
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
12.365
Reference Allele:
G
-log10(P):
-79.191
MAF:
0.298
Beta (Num):
0.064
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.166
SE (Den):
0.017
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Phospholipid biosynthesis2[1], 3[2]

Denominator Metabolite Explanation:

Glycerophosphocholine metabolism, Phospholipid biosynthesis4[1]

Ratio Explanation:

The ratio reflects the balance between glycerophosphoinositol and glycerophosphocholine pools, both major classes of phospholipids, potentially influenced by fatty acid metabolism.4[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

PDXDC1's role in regulating polyunsaturated fatty acid metabolism likely influences the composition of glycerophospholipids, impacting phenotypes like BMI, body weight, and triglyceride levels, which are closely tied to lipid and fatty acid homeostasis.1[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:PDXDC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data