1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.524
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
26.784
Reference Allele:
T
-log10(P):
-362.195
MAF:
0.347
Beta (Num):
0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.342
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA metabolism.1[1], 5[2]

Ratio Explanation:

This ratio reflects FADS enzyme activity, comparing a lipid with a precursor fatty acid (linoleic acid) to one with a product (arachidonic acid).1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter desaturase activity, impacting the balance of pro-inflammatory lipids derived from arachidonic acid.7[1], 8[2] This dysregulation influences susceptibility to inflammatory conditions like IBD, asthma, cholelithiasis, and affects lipid metabolism.9[3], 10[4], 7[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data