1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to arachidonoylcholine

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.376
Position:
61596633
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
15.771
Reference Allele:
C
-log10(P):
-127.357
MAF:
0.346
Beta (Num):
0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.193
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.6[1]

Denominator Metabolite Explanation:

Acyl-choline metabolism.7[1], 6[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and acyl-choline metabolism. FADS1/FADS2 are key enzymes in the synthesis of long-chain polyunsaturated fatty acids, influencing the composition of lipids like 1-palmitoyl-2-linoleoyl-gpi.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The FADS1/FADS2 genes influence the composition of polyunsaturated fatty acids, which are precursors for signaling molecules involved in inflammation.10[1] Altered levels of these fatty acids, reflected in the metabolite ratio, are associated with inflammatory conditions like asthma, cholelithiasis, and hypercholesterolemia.11[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data