1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.336
Position:
61596633
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
13.003
Reference Allele:
C
-log10(P):
-87.335
MAF:
0.346
Beta (Num):
0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.153
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism, PUFA biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS enzyme efficiency, contrasting a phospholipid containing an omega-6 fatty acid (linoleic acid) with a FADS-dependent very-long-chain omega-3 fatty acid (nisinate).1[1], 2[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters PUFA metabolism, which is reflected in the ratio.1[1], 8[2] This dysregulation of lipid balance influences inflammatory pathways and lipid metabolism, contributing to associated phenotypes like cholelithiasis, hypercholesterolemia, asthma, and type 2 diabetes.8[3], 9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data