1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.373
Position:
61588305
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
14.044
Reference Allele:
A
-log10(P):
-101.484
MAF:
0.344
Beta (Num):
0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Phospholipid metabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Ratio Explanation:

The ratio reflects FADS activity; the numerator contains the FADS substrate linoleic acid (18:2), while the denominator is a downstream PUFA product.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity is linked to altered PUFA levels, which can influence inflammatory pathways and lipid metabolism, contributing to phenotypes like IBD, asthma, and dyslipidemia.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data