1-palmitoyl-2-linoleoyl-gpi (16:0/18:2) to eicosapentaenoate (epa; 20:5n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Metabolite Accession: GCST90200332
Name: 1-palmitoyl-2-linoleoyl-gpi (16:0/18:2)
Hmdb Id: HMDB0009784
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSNJSZUDOMPYIR

Denominator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.386
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
17.118
Reference Allele:
A
-log10(P):
-149.583
MAF:
0.344
Beta (Num):
0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.203
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism.5[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between glycerophosphoinositol lipids and long-chain omega-3 fatty acids. FADS1/FADS2 activity directly influences the levels of EPA (denominator).2[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter enzyme activity, impacting the balance of fatty acids like EPA and complex lipids.10[1] This dysregulation is associated with hypercholesterolemia, cholelithiasis, and type 2 diabetes, phenotypes linked to altered lipid metabolism and inflammation.11[2], 10[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data