1-palmitoyl-2-oleoyl-gpc (16:0/18:1) to 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpc (16:0/18:1)
Metabolite Accession: GCST90200340
Name: 1-palmitoyl-2-oleoyl-gpc (16:0/18:1)
Hmdb Id: HMDB0007972
Super Pathway: NA
Sub Pathway: NA
Inchikey: WTJKGGKOPKCXLL

Denominator Metabolite

Structure of 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Metabolite Accession: GCST90199653
Name: 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Hmdb Id: HMDB0007869
Super Pathway: NA
Sub Pathway: NA
Inchikey: RFVFQQWKPSOBED

Associated Genomic Regions

Region: rs3134950

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.124
Position:
32127477
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
8.831
Reference Allele:
A
-log10(P):
-41.411
MAF:
0.372
Beta (Num):
0.068
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.056
SE (Den):
0.016
No CNV overlap
rQTL cluster:
107
Reaction Distance:
NA
Closest Genes:
PPT2 PPT2-EGFL8 EGFL8 PRRT1 AGPAT1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid biosynthesis.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio reflects the relative activity of enzymes in glycerophospholipid metabolism, where AGPAT1 plays a role, potentially influencing the balance of different phosphatidylcholine species.1[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The AGPAT1 gene is linked to both glycerophospholipid metabolism and phenotypes like asthma and blood pressure.1[1], 6[2], 7[3] Altered AGPAT1 function could shift the balance of phosphatidylcholine species, represented by the ratio, potentially contributing to the pathogenesis of these conditions through effects on inflammation or cell signaling.

Phenotype Driver:

Gene-centric:AGPAT1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data