1-palmitoyl-2-oleoyl-gpc (16:0/18:1) to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpc (16:0/18:1)
Metabolite Accession: GCST90200340
Name: 1-palmitoyl-2-oleoyl-gpc (16:0/18:1)
Hmdb Id: HMDB0007972
Super Pathway: NA
Sub Pathway: NA
Inchikey: WTJKGGKOPKCXLL

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs3134950

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.267
Position:
32127477
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
15.088
Reference Allele:
A
-log10(P):
-116.761
MAF:
0.372
Beta (Num):
0.068
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.199
SE (Den):
0.016
No CNV overlap
rQTL cluster:
107
Reaction Distance:
NA
Closest Genes:
PPT2 PPT2-EGFL8 EGFL8 PRRT1 AGPAT1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of 1-palmitoyl-2-oleoyl-GPC to 1,2-dipalmitoyl-GPC reflects the fatty acid composition at the sn-2 position of phosphatidylcholines, indicating altered glycerophospholipid remodeling.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Dysregulation of AGPAT1, which is involved in phospholipid biosynthesis, may alter membrane composition, contributing to inflammatory responses seen in asthma and impacting blood pressure regulation.4[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:AGPAT1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data