2-hydroxyhippurate (salicylurate) to salicylate

Numerator Metabolite

Structure of 2-hydroxyhippurate (salicylurate)
Metabolite Accession: GCST90200347
Name: 2-hydroxyhippurate (salicylurate)
Hmdb Id: HMDB0000840
Super Pathway: NA
Sub Pathway: NA
Inchikey: ONJSZLXSECQROL

Denominator Metabolite

Metabolite Accession: GCST90200421
Name: salicylate
Hmdb Id: HMDB0001895
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs9922704

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.182
Position:
20560377
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-12.367
Reference Allele:
T
-log10(P):
-79.222
MAF:
0.024
Beta (Num):
0.046
Novel Locus:
Yes ✔️
SE (Num):
0.049
Beta (Den):
0.228
SE (Den):
0.050
No CNV overlap
rQTL cluster:
28
Reaction Distance:
NA
Closest Genes:
ACSM2B AC137056.1 ACSM3 ACSM2A ACSM1

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Glycine Conjugation.3[1], 2[2], 4[3]

Denominator Metabolite Explanation:

Xenobiotic Metabolism.3[1], 1[2]

Ratio Explanation:

The ratio reflects the conversion of salicylate to 2-hydroxyhippurate, a glycine conjugation reaction initiated by the ACSM2B-catalyzed activation of salicylate.1[1], 2[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

No phenotype associations were provided, so a causal link between the genetic factors, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data