quinolinate to kynurenine

Numerator Metabolite

Structure of quinolinate
Metabolite Accession: GCST90200348
Name: quinolinate
Hmdb Id: HMDB0000232
Super Pathway: NA
Sub Pathway: NA
Inchikey: GJAWHXHKYYXBSV

Denominator Metabolite

Structure of kynurenine
Metabolite Accession: GCST90199636
Name: kynurenine
Hmdb Id: HMDB0000684
Super Pathway: NA
Sub Pathway: NA
Inchikey: YGPSJZOEDVAXAB

Associated Genomic Regions

Region: rs61825638

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.273
Position:
241713402
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-18.255
Reference Allele:
C
-log10(P):
-169.761
MAF:
0.246
Beta (Num):
-0.143
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.130
SE (Den):
0.017
No CNV overlap
rQTL cluster:
227
Reaction Distance:
3.0
Closest Genes:
KMO FH OPN3 CHML WDR64

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism/Kynurenine pathway.4[1], 5[2]

Denominator Metabolite Explanation:

Tryptophan metabolism/Kynurenine pathway.6[1], 7[2]

Ratio Explanation:

This ratio reflects the activity of KMO, which catalyzes the conversion of kynurenine to downstream metabolites, including the precursor to quinolinate.1[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data