quinolinate to kynurenate

Numerator Metabolite

Structure of quinolinate
Metabolite Accession: GCST90200348
Name: quinolinate
Hmdb Id: HMDB0000232
Super Pathway: NA
Sub Pathway: NA
Inchikey: GJAWHXHKYYXBSV

Denominator Metabolite

Structure of kynurenate
Metabolite Accession: GCST90200454
Name: kynurenate
Hmdb Id: HMDB0000715
Super Pathway: NA
Sub Pathway: NA
Inchikey: HCZHHEIFKROPDY

Associated Genomic Regions

Region: rs61825638

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.479
Position:
241713402
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-25.096
Reference Allele:
C
-log10(P):
-318.350
MAF:
0.246
Beta (Num):
-0.143
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.336
SE (Den):
0.017
No CNV overlap
rQTL cluster:
227
Reaction Distance:
4.0
Closest Genes:
KMO FH OPN3 CHML WDR64

LLM Analysis

Numerator Metabolite Explanation:

Kynurenine pathway.4[1], 5[2]

Denominator Metabolite Explanation:

Kynurenine pathway.4[1], 6[2]

Ratio Explanation:

An increased ratio reflects a shift in kynurenine metabolism away from quinolinate production and towards kynurenate production, often due to lower KMO activity.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A higher quinolinate to kynurenate ratio, indicating increased KMO activity, shifts the kynurenine pathway towards the production of neurotoxic quinolinate and away from neuroprotective kynurenate.1[1], 10[2] No associated phenotype was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data