eicosapentaenoate (epa; 20:5n3) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs99780

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.123
Position:
61596633
SE (Ratio):
0.008
Effect Allele:
T
Z-score (Ratio):
-14.677
Reference Allele:
C
-log10(P):
-110.620
MAF:
0.345
Beta (Num):
-0.202
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.079
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
4.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs3945981

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.115
Position:
11011405
SE (Ratio):
0.008
Effect Allele:
A
Z-score (Ratio):
14.243
Reference Allele:
G
-log10(P):
-104.325
MAF:
0.426
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
4.0
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 ERVFRD-1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis2[1], 5[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis2[1], 5[2]

Ratio Explanation:

This ratio reflects the efficiency of the final steps in omega-3 fatty acid synthesis, where lower FADS/ELOVL2 activity leads to higher EPA relative to DHA.6[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants are strongly associated with altered levels of circulating lipids and inflammation, which influences susceptibility to cholelithiasis and cardiovascular phenotypes.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data