eicosapentaenoate (epa; 20:5n3) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.427
Position:
61592362
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-23.103
Reference Allele:
A
-log10(P):
-270.250
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.226
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Long-chain polyunsaturated fatty acid metabolism10[1], 11[2], 12[3], 13[4], 14[5]

Ratio Explanation:

The ratio of eicosapentaenoate (EPA) to docosatrienoate (22:3n3) reflects the efficiency of delta-5 desaturation, a key step in omega-3 fatty acid metabolism catalyzed by FADS1.1[1], 15[2], 16[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster influences fatty acid metabolism, impacting inflammatory and metabolic disorders.17[1], 18[2], 19[3], 20[4] Altered FADS activity, reflected in the EPA/22:3n3 ratio, is linked to cholesterol levels and risk for cholelithiasis and cardiovascular-related conditions like valvular heart disease and pulmonary embolism.17[5], 18[6], 19[7], 20[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data