eicosapentaenoate (epa; 20:5n3) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.221
Position:
61592362
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-14.981
Reference Allele:
A
-log10(P):
-115.156
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.020
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism

Ratio Explanation:

The ratio reflects the efficiency of FADS-mediated desaturation, where higher FADS activity leads to increased EPA and potentially altered levels of other fatty acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 are associated with altered levels of long-chain polyunsaturated fatty acids, including EPA, and have been linked to an increased risk of cholelithiasis, type 2 diabetes, and dyslipidemia, likely through their influence on lipid metabolism.4[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data