eicosapentaenoate (epa; 20:5n3) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.215
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-14.960
Reference Allele:
A
-log10(P):
-114.838
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.014
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio of eicosapentaenoate to 10-heptadecenoate is an indicator of FADS1/FADS2 enzyme activity, reflecting the efficiency of converting fatty acid precursors to EPA.1[1], 2[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 influence the levels of long-chain polyunsaturated fatty acids.10[1], 11[2] This altered lipid profile, particularly related to EPA, is associated with various phenotypes including pure hypercholesterolaemia, cholelithiasis, and asthma, likely through effects on inflammation and lipid metabolism.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data