eicosapentaenoate (epa; 20:5n3) to eicosenoate (20:1)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.222
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-15.389
Reference Allele:
A
-log10(P):
-121.380
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.021
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio of eicosapentaenoate to eicosenoate reflects the activity of FADS1 and FADS2 enzymes, which are involved in the desaturation of fatty acids.2[1], 1[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster influence the efficiency of polyunsaturated fatty acid synthesis, impacting the eicosapentaenoate to eicosenoate ratio.1[1], 2[2] This altered lipid metabolism is associated with a range of phenotypes including cardiovascular diseases like valvular heart disease and hypercholesterolemia, and inflammatory conditions such as asthma.5[3], 6[4], 7[5], 8[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data