eicosapentaenoate (epa; 20:5n3) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.214
Position:
61593005
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-15.356
Reference Allele:
A
-log10(P):
-120.867
MAF:
0.346
Beta (Num):
-0.202
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.012
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis; Eicosanoid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis; Linoleate metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the enzymatic efficiency of converting linolenate (a precursor) into eicosapentaenoate (a long-chain polyunsaturated fatty acid) by FADS enzymes.11[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, thereby influencing the eicosapentaenoate to linolenate ratio.12[1], 13[2], 3[3] This imbalance in fatty acids is associated with an increased risk for inflammatory conditions, cardiovascular diseases like valvular heart disease and phlebitis, and metabolic disorders such as type 2 diabetes and hypercholesterolemia.12[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data