eicosapentaenoate (epa; 20:5n3) to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Metabolite Accession: GCST90199995
Name: sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.392
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-17.860
Reference Allele:
C
-log10(P):
-162.600
MAF:
0.339
Beta (Num):
-0.205
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.186
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the balance between polyunsaturated fatty acid synthesis (numerator) and sphingolipid synthesis (denominator), both influenced by FADS gene activity.11[1], 12[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants influence the synthesis of EPA.1[1], 2[2] Altered levels of EPA and other fatty acids are associated with inflammatory conditions like asthma and IBD, and cardiovascular phenotypes like valvular heart disease and cholelithiasis, potentially through modulation of inflammation.13[3], 14[4], 15[5], 16[6], 17[7], 18[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data