eicosapentaenoate (epa; 20:5n3) to linoleoyl ethanolamide

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.281
Position:
61569830
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-14.905
Reference Allele:
C
-log10(P):
-114.004
MAF:
0.339
Beta (Num):
-0.205
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.076
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
10.0
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

N-acylethanolamine biosynthesis6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between omega-3 fatty acid (eicosapentaenoate) synthesis and endocannabinoid-like molecule (linoleoyl ethanolamide) production, influenced by FADS desaturase activity.3[1], 9[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster impact the activity of FADS1 and FADS2 enzymes, altering the levels of polyunsaturated fatty acids like eicosapentaenoate.3[1], 9[2], 11[3], 12[4] This dysregulation of fatty acid metabolism is associated with various disorders, including cholelithiasis, type 2 diabetes, and asthma.13[5], 14[6], 15[7], 16[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data