eicosapentaenoate (epa; 20:5n3) to oleate/vaccenate (18:1)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.213
Position:
61592362
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-14.478
Reference Allele:
A
-log10(P):
-107.705
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.012
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
11.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Monounsaturated fatty acid (MUFA) biosynthesis, Fatty acid degradation.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio reflects the efficiency of converting fatty acid precursors into long-chain polyunsaturated fatty acids like EPA, catalyzed by FADS enzymes.13[1], 2[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting the balance of pro-inflammatory and anti-inflammatory fatty acids.13[1], 14[2] This dysregulation of lipid metabolism is associated with various cardiometabolic and inflammatory phenotypes, including hypercholesterolemia, cholelithiasis, and asthma.3[3], 15[4], 16[5], 17[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data