eicosapentaenoate (epa; 20:5n3) to 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Metabolite Accession: GCST90200046
Name: 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Hmdb Id: HMDB0008057
Super Pathway: NA
Sub Pathway: NA
Inchikey: FAUYAENFVCNTAL

Associated Genomic Regions

Region: rs9295741

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.177
Position:
10997166
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
10.976
Reference Allele:
C
-log10(P):
-62.870
MAF:
0.420
Beta (Num):
0.044
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.133
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 ERVFRD-1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Omega-3 fatty acid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of EPA to a DHA-containing phospholipid reflects ELOVL2 enzymatic activity; higher activity consumes the numerator (EPA) to produce a constituent of the denominator (DHA).2[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in ELOVL2 can alter its enzymatic efficiency in converting EPA to DHA, thus modifying the ratio of these critical polyunsaturated fatty acids.8[1], 3[2], 9[3] No phenotype link was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data