eicosapentaenoate (epa; 20:5n3) to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.413
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-19.129
Reference Allele:
C
-log10(P):
-186.135
MAF:
0.339
Beta (Num):
-0.205
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.208
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the efficiency of converting linoleic acid to EPA, a process where FADS1 and FADS2 are rate-limiting.4[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 alter the activity of desaturase enzymes, influencing the production of EPA.1[1], 2[2] This altered EPA level and the subsequent balance with other fatty acids can impact inflammatory responses and lipid profiles, contributing to the risk of conditions like cardiovascular disease, type 2 diabetes, and inflammatory disorders.7[3], 8[4], 9[5], 10[6], 11[7], 12[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data