eicosapentaenoate (epa; 20:5n3) to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.475
Position:
61569830
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-23.661
Reference Allele:
C
-log10(P):
-283.322
MAF:
0.339
Beta (Num):
-0.205
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.270
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism6[1], 7[2]

Ratio Explanation:

The ratio of eicosapentaenoic acid to 1-palmitoleoyl-2-linolenoyl-GPC reflects the activity of FADS1/FADS2 in converting shorter-chain fatty acids into the long-chain polyunsaturated fatty acid EPA.4[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a lower ratio, is associated with an altered lipid profile, including lower HDL-C, which is a risk factor for type 2 diabetes and cholelithiasis.9[1], 10[2], 11[3], 12[4] Higher EPA levels have been shown to be protective against cholelithiasis and improve glycemic control.13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data