eicosapentaenoate (epa; 20:5n3) to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs1535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.210
Position:
61597972
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-15.407
Reference Allele:
A
-log10(P):
-121.658
MAF:
0.343
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.009
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism

Ratio Explanation:

The ratio reflects the relative activity of omega-3 versus omega-6 fatty acid synthesis pathways, which are both influenced by FADS enzymes.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the balance of omega-3 (e.g., EPA) and omega-6 fatty acids.3[1], 2[2] This imbalance is linked to inflammation and metabolic dysregulation, contributing to phenotypes like cholelithiasis, type 2 diabetes, and inflammatory conditions.4[3], 5[4], 6[5], 7[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data