eicosapentaenoate (epa; 20:5n3) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.173
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
9.685
Reference Allele:
G
-log10(P):
-49.407
MAF:
0.177
Beta (Num):
0.045
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174566

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.209
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-14.580
Reference Allele:
A
-log10(P):
-109.196
MAF:
0.345
Beta (Num):
-0.201
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis, Eicosanoid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between polyunsaturated (eicosapentaenoate) and monounsaturated (palmitoleate) fatty acid synthesis, influenced by FADS1/FADS2 desaturase activity.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster alter the activity of FADS1 and FADS2 enzymes, which affects the balance of polyunsaturated and monounsaturated fatty acids.7[1], 10[2], 11[3], 12[4] This altered lipid profile is associated with an increased risk for cholelithiasis and cardiovascular diseases like coronary atherosclerosis.7[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data