laurate (12:0) to myristoleate (14:1n5)

Numerator Metabolite

Structure of laurate (12:0)
Metabolite Accession: GCST90200350
Name: laurate (12:0)
Hmdb Id: HMDB0000638
Super Pathway: NA
Sub Pathway: NA
Inchikey: POULHZVOKOAJMA

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
0.146
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
8.934
Reference Allele:
G
-log10(P):
-42.337
MAF:
0.176
Beta (Num):
0.049
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.097
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, desaturation.4[1], 5[2]

Ratio Explanation:

This ratio reflects SCD-mediated desaturation activity. An elevated ratio of laurate (related to the substrate) to myristoleate (the product) suggests lower enzyme efficiency.6[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SCD activity, indicated by an increased laurate/myristoleate ratio, alters fatty acid composition. This dysregulation of lipid metabolism contributes to hypercholesterolaemia, atherosclerosis, and associated cardiovascular diseases like myocardial infarction.7[1], 8[2]

Phenotype Driver:

Gene-centric:[SCD]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data