laurate (12:0) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of laurate (12:0)
Metabolite Accession: GCST90200350
Name: laurate (12:0)
Hmdb Id: HMDB0000638
Super Pathway: NA
Sub Pathway: NA
Inchikey: POULHZVOKOAJMA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.161
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
10.075
Reference Allele:
G
-log10(P):
-53.295
MAF:
0.176
Beta (Num):
0.049
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1]

Ratio Explanation:

The ratio of laurate (12:0) to 5-dodecenoate (12:1n7) reflects the activity of desaturase enzymes like SCD, which convert saturated to monounsaturated fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the laurate to 5-dodecenoate ratio, is associated with changes in lipid profiles.5[1] These changes are linked to an increased risk of coronary atherosclerosis, hypercholesterolemia, and other related cardiovascular and metabolic disorders.6[2], 7[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data