laurate (12:0) to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of laurate (12:0)
Metabolite Accession: GCST90200350
Name: laurate (12:0)
Hmdb Id: HMDB0000638
Super Pathway: NA
Sub Pathway: NA
Inchikey: POULHZVOKOAJMA

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.522
Position:
21331549
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-27.161
Reference Allele:
T
-log10(P):
-372.381
MAF:
0.155
Beta (Num):
-0.016
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.506
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.5[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism or transport, where SLCO1B1 could influence the clearance of these fatty acids from circulation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function may alter lipid transport, contributing to dyslipidemia, which is a risk factor for coronary atherosclerosis and can be associated with cardiac arrhythmias.8[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data