linoleate (18:2n6) to 3-hydroxylaurate

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.123
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.469
Reference Allele:
G
-log10(P):
-47.315
MAF:
0.318
Beta (Num):
0.018
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.105
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis; beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Ratio Explanation:

THEM4, an acyl-CoA thioesterase, may influence the balance between linoleate, a long-chain fatty acid, and 3-hydroxylaurate, a product of alternative fatty acid oxidation.7[1], 8[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered fatty acid metabolism, influenced by THEM4, may contribute to the chronic low-grade inflammation observed in diverticular disease.9[1], 10[2] High fat intake is a risk factor for diverticular disease, and this ratio may reflect this dysregulation.11[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data