linoleate (18:2n6) to adrenate (22:4n6)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.199
Position:
61569830
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
17.789
Reference Allele:
C
-log10(P):
-161.336
MAF:
0.339
Beta (Num):
0.016
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.183
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid metabolism

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism

Ratio Explanation:

This ratio reflects the efficiency of converting linoleate to its downstream product, adrenate, a process mediated by FADS1 and FADS2 enzymes.5[1], 6[2], 3[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster regulate the conversion of linoleate to adrenate.1[1], 5[2] This alters the balance of omega-6 fatty acids, which are precursors to inflammatory mediators, plausibly influencing inflammatory and metabolic phenotypes like asthma, IBD, T2D, and cholelithiasis.7[3], 8[4], 9[5], 10[6], 11[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data