linoleate (18:2n6) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.282
Position:
61595564
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-15.947
Reference Allele:
C
-log10(P):
-130.149
MAF:
0.179
Beta (Num):
-0.003
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.278
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.1[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.1[1], 6[2], 5[3]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes, comparing the precursor linoleate (omega-6) to a downstream docosatrienoate (omega-3), indicating metabolic flux balance.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the balance of pro-inflammatory omega-6 and anti-inflammatory omega-3 fatty acids, reflected by the ratio. This imbalance may predispose individuals to inflammatory and allergic conditions like asthma, dermatitis, and sinusitis, and also affects lipid and hematological traits.10[1], 11[2], 12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data