linoleate (18:2n6) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.158
Position:
61569830
SE (Ratio):
0.010
Effect Allele:
T
Z-score (Ratio):
16.128
Reference Allele:
C
-log10(P):
-133.065
MAF:
0.339
Beta (Num):
0.016
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.142
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid (omega-6) metabolism3[1]

Denominator Metabolite Explanation:

Docosapentaenoic acid (omega-3) metabolism4[1], 5[2]

Ratio Explanation:

The ratio reflects the balance between omega-6 and omega-3 fatty acid synthesis, which is influenced by FADS desaturase activity.1[1], 2[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the efficiency of long-chain polyunsaturated fatty acid synthesis, affecting the balance between pro-inflammatory omega-6 and anti-inflammatory omega-3 pathways.7[1], 8[2], 9[3] This dysregulation is associated with metabolic and inflammatory conditions like cholelithiasis, type 2 diabetes, and hypercholesterolemia.7[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data