linoleate (18:2n6) to stearidonate (18:4n3)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.136
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
11.829
Reference Allele:
A
-log10(P):
-72.670
MAF:
0.345
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
3.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid metabolism

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between omega-6 (linoleate) and omega-3 (stearidonate) pathways, which are competitively regulated by FADS1/FADS2 enzyme activity.1[1], 2[2], 3[3], 4[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the balance between pro-inflammatory omega-6 and anti-inflammatory omega-3 fatty acids.5[1], 6[2], 7[3] This dysregulation of inflammatory mediators is associated with metabolic and inflammatory conditions including hypercholesterolemia, asthma, and cholelithiasis, which are reported as associated phenotypes.5[4], 7[5], 8[6], 9[7], 10[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data