linoleate (18:2n6) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.189
Position:
61597212
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
10.457
Reference Allele:
C
-log10(P):
-57.254
MAF:
0.131
Beta (Num):
0.027
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis

Denominator Metabolite Explanation:

Omega-6 fatty acid biosynthesis

Ratio Explanation:

The ratio of linoleate to its downstream product docosapentaenoate reflects the efficiency of the FADS-mediated omega-6 fatty acid conversion pathway.4[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 and FADS2 alters the linoleate to docosapentaenoate ratio, impacting the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids.7[1], 8[2], 9[3] This dysregulation is linked to cardiometabolic diseases, including lipid disorders and type 2 diabetes, and an increased risk of skin cancer.10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data