linoleate (18:2n6) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.139
Position:
15979744
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
8.242
Reference Allele:
C
-log10(P):
-36.312
MAF:
0.296
Beta (Num):
0.043
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, fatty acid omega-oxidation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2]

Ratio Explanation:

This ratio may reflect CYP4F2 activity, where the enzyme hydroxylates fatty acids like linoleate, initiating a pathway that produces dicarboxylic acids, including hexadecanedioate.3[1], 9[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity can alter the balance of its substrates and products, including linoleate and various eicosanoids, potentially promoting inflammation and endothelial dysfunction, which are key factors in the development of coronary atherosclerosis and ischaemic heart disease.11[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data