linoleate (18:2n6) to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs61897793

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.148
Position:
61599347
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-12.322
Reference Allele:
G
-log10(P):
-78.658
MAF:
0.181
Beta (Num):
-3.00e-04
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.147
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
5.0
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.101
Position:
15150505
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-9.984
Reference Allele:
C
-log10(P):
-52.380
MAF:
0.291
Beta (Num):
-0.001
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.100
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
5.0
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism

Ratio Explanation:

This ratio reflects FADS2 enzymatic activity; a higher ratio indicates lower efficiency in converting the precursor linoleate (numerator) to its downstream product dihomo-linolenate (denominator).4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS2 alter its desaturase activity, affecting the balance of n-6 fatty acids. This dysregulation of lipid metabolism can influence inflammatory pathways, contributing to phenotypes like dermatitis, sinusitis, and altered blood lipid profiles.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data