linoleate (18:2n6) to n-oleoyltaurine

Numerator Metabolite

Metabolite Accession: GCST90200354

Name: linoleate (18:2n6)

Hmdb Id: HMDB0006270,HMDB0000673

Super Pathway: NA

Sub Pathway: NA

Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Metabolite Accession: GCST90199912

Name: n-oleoyltaurine

Hmdb Id: HMDB0242113

Super Pathway: NA

Sub Pathway: NA

Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.260

Position:

46870761

SE (Ratio):

0.017

Effect Allele:

Z-score (Ratio):

-15.212

Reference Allele:

-log10(P):

-118.661

MAF:

0.208

Beta (Num):

-0.021

Novel Locus:

SE (Num):

0.018

Beta (Den):

0.239

SE (Den):

0.019

No CNV overlap

rQTL cluster:

164

Reaction Distance:

Closest Genes:

FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Fatty acid amide catabolism

Ratio Explanation:

This ratio likely reflects FAAH enzyme activity; lower activity results in higher levels of the substrate N-oleoyltaurine relative to the broader fatty acid pool.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype link was provided in the input data. Reduced FAAH activity, indicated by an elevated ratio, is associated with various neurological and metabolic phenotypes, but a specific causal chain cannot be established here.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data