linoleate (18:2n6) to linoleoyl ethanolamide

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.245
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-14.182
Reference Allele:
C
-log10(P):
-103.453
MAF:
0.208
Beta (Num):
-0.021
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.224
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, omega-6 fatty acid metabolism.11[1], 12[2], 13[3]

Denominator Metabolite Explanation:

N-acylethanolamine biosynthesis, endocannabinoid signaling.14[1], 15[2], 16[3], 17[4]

Ratio Explanation:

This ratio may reflect FAAH enzyme activity, where reduced function leads to accumulation of linoleoyl ethanolamide relative to its precursor linoleate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH reduces its activity, leading to an increase in its substrate, linoleoyl ethanolamide, relative to linoleate. No direct phenotype link is established in the provided data.

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data