linoleate (18:2n6) to stearate (18:0)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.093
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-8.094
Reference Allele:
G
-log10(P):
-35.089
MAF:
0.176
Beta (Num):
0.004
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, polyunsaturated fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, saturated fatty acid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects Stearoyl-CoA desaturase (SCD) activity; decreased enzyme activity leads to stearate accumulation, thus lowering the ratio of linoleate to stearate.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in SCD alters its activity, reflected in the linoleate/stearate ratio. This dysregulation of fatty acid metabolism is associated with cardiometabolic phenotypes like coronary atherosclerosis, pure hypercholesterolaemia, and myocardial infarction.8[1], 10[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data